Low level of immunoglobulin G2a subclass correlates with a deficiency in T helper cell function in LEC mutant rats.

doi:10.1292/jvms.57.527

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Article

Low level of immunoglobulin G2a subclass correlates with a deficiency in T helper cell function in LEC mutant rats.

The Journal of veterinary medical science - 1 Jun 1995

Sakai T, Agui T, Muramatsu Y, Nagasawa H, Himeno K, Matsumoto K

Abstract excerpt

Long-Evans Cinnamon (LEC) rats bear a congenital deficiency in CD4+8- thymocytes and consequently a deficiency in helper T cell function. This mutation is caused by a single recessive gene referred to as thid (T helper immunodeficiency). It has been reported that rat immunoglobulin(Ig) G2a subclass is a counterpart of the mouse IgG1. Serum IgG2a levels in LEC rats were ten-fold lower than those of normal rats. To...

Topics

Animals
Antibodies, Monoclonal
B-Lymphocytes
CD4 Antigens
CD8 Antigens
Crosses, Genetic
Enzyme-Linked Immunosorbent Assay
Genes, Recessive
Genetic Linkage
Immunoglobulin G
Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Phenotype

Rats

Rats, Inbred F344

Rats, Mutant Strains

Reference Values

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 7548412
DOI: 10.1292/jvms.57.527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7548412-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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