Article
Genetic analysis of growth inhibition by GAL4-L kappa B-alpha in Saccharomyces cerevisiae.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1995
Morin P J, Downs J A, Snodgrass A M, Gilmore T D
Abstract excerpt
I kappa B proteins bind to and regulate Rel/NF- kappa B transcription factors. We showed previously that a fusion protein (GAL4-p40) containing the DNA-binding domain of GAL4 and sequences of chicken l kappa B-alpha (p40) inhibits growth in the yeast Saccharomyces cerevisiae. We now show that p40 must be bound to DNA to inhibit yeast growth, p40 proteins, bound to DNA either as GAL4 or LEXA fusion proteins,...
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