Article
Structure and nuclear localization signal of the SKI3 antiviral protein of Saccharomyces cerevisiae.
Yeast (Chichester, England) - 1 Jan 2000
Rhee S K, Icho T, Wickner R B
Abstract excerpt
The yeast chromosomal genes SKI2, SKI3, SKI4, SKI6, SKI7 and SKI8 repress the replication of double-stranded RNA viruses, protecting the host from the otherwise lethal effects of the virus. We cloned and sequenced the SKI3 gene and found that it encodes a 163 kDa protein including a typical nuclear localization signal. Cell fractionation experiments show that the SKI3 gene product is indeed tightly associated...
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