The impact of glutathione s-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-DNA adduct levels in humans.

doi:10.1002/mc.2940140111

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Article

The impact of glutathione s-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-DNA adduct levels in humans.

Molecular carcinogenesis - 1 Sept 1995

Rothman N, Shields P G, Poirier M C, Harrington A M, Ford D P, Strickland P T

Abstract excerpt

Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). PAH-DNA adducts can be measured in peripheral white blood cells (WBCs) and should reflect the net effect of competing activation...

Topics

Cooking
Cytochrome P-450 Enzyme System
DNA Adducts
Enzyme-Linked Immunosorbent Assay
Exons
Fires
Genotype
Glutathione Transferase
Humans
Inactivation, Metabolic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Leukocytes

Meat

Occupational Exposure

Polycyclic Aromatic Hydrocarbons

Polycyclic Compounds

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7546226
DOI: 10.1002/mc.2940140111

Genes

PAH
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7546226-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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