Article
Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.
Nucleic acids research - 11 Aug 1995
Sun L Q, Wang L, Gerlach W L, Symonds G
Abstract excerpt
The structural motif formed between a hammerhead ribozyme and its substrate consists of three RNA double helices in which the sequence 5' to the XUY is termed helix I and the sequence 3' to the XUY helix III. Two hammerhead ribozymes targeted to the tat gene of HIV-1SF2 were designed to study tar...
Topics
- Base Sequence
- Cell Line
- Codon, Initiator
- Genes, tat
- Genetic Variation
- HIV-1
- Humans
- Kanamycin Kinase
- Molecular Sequence Data
- Nucleic Acid Conformation
- Nucleic Acid Heteroduplexes
- Phosphotransferases (Alcohol Group Acceptor)
- RNA
- RNA Splicing
- RNA, Catalytic
- RNA, Viral
- Sequence Analysis, DNA
- T-Lymphocytes, Regulatory