Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.

Nucleic acids research - 11 Aug 1995

Sun L Q, Wang L, Gerlach W L, Symonds G

Abstract excerpt

The structural motif formed between a hammerhead ribozyme and its substrate consists of three RNA double helices in which the sequence 5' to the XUY is termed helix I and the sequence 3' to the XUY helix III. Two hammerhead ribozymes targeted to the tat gene of HIV-1SF2 were designed to study target specificity and the potential effect of helix I mismatch on ribozyme efficacy both in vitro and in vivo. The first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Nucleic Acid Conformation

Share to RNA, Viral

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 7544887
DOI: 10.1093/nar/23.15.2909
PMCID: PMC307129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.PMID 7544887Read ↗

Long‐term survival and concomitant gene expression of ribozyme‐transduced CD4+ T‐lymphocytes in HIV‐infected patientsSemantic proximity Read ↗

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.Semantic proximity Read ↗

Splicing efficiency of human immunodeficiency virus type 1 tat RNA is determined by both a suboptimal 3' splice site and a 10 nucleotide exon splicing silencer element located within tat exon 2Semantic proximity Read ↗

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.Semantic proximity Read ↗

Hairpin ribozymes in combination with siRNAs against highly conserved hepatitis C virus sequence inhibit RNA replication and protein translation from hepatitis C virus subgenomic repliconsSemantic proximity Read ↗

Detection, characterization and regulation of antisense transcripts in HIV-1Semantic proximity Read ↗

HIV-1 nucleocapsid protein zinc finger structures induce tRNA(Lys,3) structural changes but are not critical for primer/template annealing.Semantic proximity Read ↗

Multivalent anti-CCR ribozymes for stem cell-based HIV type 1 gene therapy.Semantic proximity Read ↗

A stable hammerhead structure is not required for endonucleolytic activity of a ribozyme in vivo.Semantic proximity Read ↗

Specificity of the hairpin ribozyme. Sequence requirements surrounding the cleavage site.Semantic proximity Read ↗

Importance of A-loop complementarity with tRNAHis anticodon for continued selection of tRNAHis as the HIV reverse transcription primer.Semantic proximity Read ↗

The role of the tnv protein and tnv RNA splicing signals in replication of HIV-1 IIIB isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.