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Article

Specificity of the hairpin ribozyme. Sequence requirements surrounding the cleavage site.

The Journal of biological chemistry - 8 Oct 1999

Pérez-Ruiz M, Barroso-DelJesus A, Berzal-Herranz A

Abstract excerpt

Substrate sequence requirements of the hairpin ribozyme have been partially defined by both mutational and in vitro selection experiments. It was considered that the best targets were those that included the N downward arrowGUC sequence surrounding the cleavage site. In contrast to previous studies that failed to evaluate all possible combinations of these nucleotides, we have performed an exhaustive analysis of...

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Source

Identifiers

PMID: 10506198
DOI: 10.1074/jbc.274.41.29376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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