Article
Glutathione-S-transferase activity and multidrug resistance phenotype in chronic lymphocytic leukemia: do they have any clinical relevance?
Haematologica - 1 Jan 2000
Di Simone D, Testi R, Caracciolo F, Capochiani E, Ambrogi F, Grassi B, Petrini M
Abstract excerpt
BACKGROUND: Lymphocytes from patients affected by B-cell chronic lymphocytic leukemia (B-CLL) have frequently been shown to be positive for the multidrug resistance (MDR) phenotype. However, this phenotype does not seem to be responsible for the resistance to alkylating agents usually employed in...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adult
- Aged
- Aged, 80 and over
- Alkylating Agents
- Antigens, CD
- Antigens, CD19
- Antigens, Differentiation, B-Lymphocyte
- CD5 Antigens
- Chlorambucil
- Drug Resistance, Multiple
- Female
- Glutathione Transferase
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Middle Aged
- Neoplasm Proteins