Article
MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibility and prognosis.
Medical oncology (Northwood, London, England) - 1 Dec 2011
Penna G, Allegra A, Alonci A, Aguennouz M, Garufi A, Cannavò A, Gerace D, Alibrandi A, Musolino C
Abstract excerpt
Patients with B-chronic lymphocytic leukemia present diverse clinical features, genetic abnormalities, variable response to treatment, and heterogeneous prognosis. Novel biological markers such as IgVH mutation, CD38, and ZAP-70 expression have shown to offer important prognostic information. An altered expression of the multidrug resistance 1 may represent an additional prognostic marker. Aim of our study was to...
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