Article
A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation.
Biochemistry - 18 Jul 1995
Guay-Broder C, Jacobson K A, Barnoy S, Cabantchik Z I, Guggino W B, Zeitlin P L, Turner R J, Vergara L, Eidelman O, Pollard H B
Abstract excerpt
Cystic fibrosis is an autosomal recessive disorder affecting chloride transport in pancreas, lung, and other tissues, which is caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). The A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (CPX) stimulates 36Cl- efflux fro...
Topics
- Animals
- Cell Line
- Chlorides
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Humans
- Ion Transport
- Membrane Proteins
- Mice
- Mutation
- Potassium