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Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems.

Nanotoxicology - 1 Jun 2013

Kato Tatsuya, Totsuka Yukari, Ishino Kousuke, Matsumoto Yoko, Tada Yukie, Nakae Dai, Goto Sumio, Masuda Shuichi, Ogo Sayaka, Kawanishi Masanobu, Yagi Takashi, Matsuda Tomonari, Watanabe Masatoshi, Wakabayashi Keiji

Abstract excerpt

The genotoxic effects of multi-walled carbon nanotubes (MWCNTs) were examined by using in vitro and in vivo assays. MWCNTs significantly induced micronuclei in A549 cells and enhanced the frequency of sister chromatid exchange (SCE) in CHO AA8 cells. When ICR mice were intratracheally instilled with a single dose (0.05 or 0.2 mg/animal) of MWCNTs, DNA damage of the lungs, analysed by comet assay, increased in a...

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PMID: 22397533
DOI: 10.3109/17435390.2012.674571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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