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Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points.

Mutagenesis - 1 Sept 2005

Deng Hongping, Zhang Meibian, He Jiliang, Wu Wei, Jin Lifen, Zheng Wei, Lou Jianlin, Wang Baohong

Abstract excerpt

Genetic damage in workers occupationally exposed to an antineoplastic drug was studied using the micronucleus (MN) test, the comet assay, the hprt gene mutation assay and the TCR gene mutation assay. The subjects were divided into two groups: (i) 21 workers from a plant producing methotrexate (MTX); (ii) 21 controls were matched according to age, gender and smoking. Fresh blood samples were collected from the...

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Identifiers

PMID: 16037120
DOI: 10.1093/mutage/gei048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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