Article
Genetic mosaicism at the insulin locus in liver associated with childhood hepatoblastoma.
Genes, chromosomes & cancer - 1 May 1995
Simms L A, Reeve A E, Smith P J
Abstract excerpt
Hepatoblastoma is commonly associated with loss of heterozygosity (LOH) involving chromosome region 11p15.5. This region may contain an as yet unidentified tumor suppressor gene relevant to this and other tumors associated with the Beckwith-Wiedemann syndrome. Using the insulin (INS) locus as a marker for this region we have identified two of three patients with hepatoblastoma whose livers demonstrated genetic...
Topics
- Alleles
- Blotting, Southern
- Child
- Child, Preschool
- Chromosomes, Human, Pair 11
- Genetic Markers
- Hepatoblastoma
- Heterozygote
- Humans
- Insulin
- Liver Neoplasms
- Mosaicism