Article
Gene targeting for inflammatory cell adhesion molecules.
Agents and actions. Supplements - 1 Jan 1995
Bullard D C, Sandberg E T, Scharffetter-Kochanek K, Beaudet A L
Abstract excerpt
Using gene targeting in mouse embryonic stem cells, it is possible to introduce diverse mutations into specific genes. Using these methods, various laboratories have reported mutations for a variety of inflammatory cell adhesion molecules including CD18, alpha 5 integrin, ICAM-1, P-selectin, and L-selectin; preliminary reports of other mutations are also available. Mutations in CD18 and ICAM-1 cause impaired...
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