Article
Changes in the concentrations of extracellular Mg++ and Ca++ down-regulate E-cadherin and up-regulate alpha 2 beta 1 integrin function, activating keratinocyte migration on type I collagen.
The Journal of investigative dermatology - 1 May 1995
Grzesiak J J, Pierschbacher M D
Abstract excerpt
We have demonstrated recently that shifts in the concentrations of extracellular Mg++ and Ca++ occur during cutaneous injury in vivo. These shifts correlate well with the timing of migration of various cell types involved in wound healing, including keratinocytes. In the present study, we examine...
Topics
- Antigens, CD
- Cadherins
- Calcium
- Cell Communication
- Cell Line, Transformed
- Cell Movement
- Collagen
- Culture Media
- Down-Regulation
- Extracellular Space
- Humans
- Integrin alpha2