Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner.

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Article

Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner.

The Journal of biological chemistry - 21 Oct 1994

Kamata T, Takada Y

Abstract excerpt

Integrin alpha 2 beta 1 is a major divalent cation-dependent receptor for collagen. Here, we show that the recombinant inserted/interactive domain (I domain) of alpha 2 specifically interacts with collagen, indicating the I domain contains all the components necessary for collagen binding. Eviden...

Topics

Animals
Antigens, CD
Base Sequence
Binding Sites
CHO Cells
Collagen
Cricetinae
Edetic Acid
Glutathione Transferase
Integrin beta1
Integrins
Magnesium
Manganese
Molecular Sequence Data
Mutation
Recombinant Fusion Proteins
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 7523399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7523399-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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