Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells.

Cancer science - 1 Aug 2008

Grzesiak John J, Bouvet Michael

Abstract excerpt

We have previously demonstrated that pathophysiological shifts in the concentrations of extracellular Mg(2+) and Ca(2+) activate the alpha(2)beta(1) integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells, as evidenced by increased adhesion, migration and proliferation. In the present study, we examined the integrin and divalent cation specificity of pancreatic cancer cell interactions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cations
Share to Collagen Type IV
Share to Fibronectins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrin beta1

Share to Integrins

Share to Laminin

Share to Magnesium

Share to Vitronectin

Source

Open in PubMed Open full text

Identifiers

PMID: 18754866
DOI: 10.1111/j.1349-7006.2008.00855.x
PMCID: PMC11159898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells.PMID 18754866Read ↗

Activation of the alpha2beta1 integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells by shifts in the concentrations of extracellular Mg2+ and Ca2+.Semantic proximity Read ↗

The integrin-extracellular matrix axis in pancreatic cancer.Semantic proximity Read ↗

The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines.Semantic proximity Read ↗

Changes in the concentrations of extracellular Mg++ and Ca++ down-regulate E-cadherin and up-regulate alpha 2 beta 1 integrin function, activating keratinocyte migration on type I collagen.Semantic proximity Read ↗

GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells.Semantic proximity Read ↗

Role of integrins in melanocyte attachment and dendricitySemantic proximity Read ↗

Integrin‐mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral discSemantic proximity Read ↗

Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation.Semantic proximity Read ↗

Alpha integrin subunits regulate human (Caco-2) intestinal epithelial proliferation and phenotype.Semantic proximity Read ↗

Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein.Semantic proximity Read ↗

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.Semantic proximity Read ↗

Inherited mutations within the calcium-binding sites of the integrin alpha IIb subunit (platelet glycoprotein IIb). Effects of the amino acid side chain and the amino acid position on cation binding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.