Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells.

doi:10.1111/j.1349-7006.2008.00855.x

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Article

Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells.

Cancer science - 1 Aug 2008

Grzesiak John J, Bouvet Michael

Abstract excerpt

We have previously demonstrated that pathophysiological shifts in the concentrations of extracellular Mg(2+) and Ca(2+) activate the alpha(2)beta(1) integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells, as evidenced by increased adhesion, migration and proliferation. In the present study, we examined the integrin and divalent cation specificity of pancreatic cancer cell interactions...

Topics

Calcium
Cations
Cell Adhesion
Cell Proliferation
Collagen Type IV
Fibronectins
Humans
Integrin alpha2beta1
Integrin beta1
Integrins
Laminin
Magnesium
Pancreatic Neoplasms
Phenotype
Tumor Cells, Cultured
Vitronectin

Source

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Identifiers

PMID: 18754866
DOI: 10.1111/j.1349-7006.2008.00855.x
PMCID: PMC11159898

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