Article
RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas.
Biochemical and biophysical research communications - 6 Feb 1995
Morelli A, Falchetti A, Weinstein L, Fabiani S, Tomassetti P, Enzi G, Carraro R, Bordi C, Tonelli F, Brandi M L
Abstract excerpt
Six lipomas from patients affected by Multiple Symmetric Lipomatosis (MSL) and by Multiple Endocrine Neoplasia Type 1 (MEN 1) were analyzed for loss of heterozygosity on chromosome 11 region q12-13 using four RFLPs. Allelic loss for the D11S146 locus was found only in one visceral MEN 1-associated lipoma. Lipomas that exhibited a lack of allelic lesions were analyzed for an eventual abnormal amount or a defective...
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