Article
Oligoribonuclease is an essential component of the mRNA decay pathway.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 1999
Ghosh S, Deutscher M P
Abstract excerpt
mRNA decay in prokaryotic cells involves the action of both endo- and exoribonucleases. In Escherichia coli, degradation of RNA to the mononucleotide level was thought to depend on RNase II and polynucleotide phosphorylase. Here, we show that the enzyme oligoribonuclease is an essential part of this process as well. Thus, inactivation of the orn gene encoding oligoribonuclease leads to a cessation of cell growth....
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