Article
An in vivo model for receptor tyrosine kinase autocrine/paracrine activation: auto-stimulated KIT receptor acts as a tumor promoting factor in papillomavirus-induced tumorigenesis.
Oncogene - 19 Jan 1995
Kondoh G, Hayasaka N, Li Q, Nishimune Y, Hakura A
Abstract excerpt
Constitutive overactivation of growth factor receptors through autocrine/paracrine mechanisms occurs frequently in cancer cells and are thought to play a critical role in carcinogenesis. In the present report, we propose a refined in vivo model which explains the significance of these mechanisms in tumour development. We have previously established transgenic mouse lines containing human papillomavirus type 16...
Topics
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Cell Division
- Hematopoietic Cell Growth Factors
- Leydig Cell Tumor
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation