Article
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.
Cancer cell - 17 May 2011
Vijayakumar Sapna, Liu Guizhong, Rus Ioana A, Yao Shen, Chen Yan, Akiri Gal, Grumolato Luca, Aaronson Stuart A
Abstract excerpt
Wnt canonical signaling is critical for normal development as well as homeostasis of several epithelial tissues, and constitutive activation of this pathway is commonly observed in carcinomas. We show here that 50% of human sarcomas (n = 45) and 65% of sarcoma cell lines (n = 23) of diverse histological subtypes exhibit upregulated autocrine canonical Wnt signaling. Furthermore, in Wnt autocrine cell lines, we...
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