Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression.

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Article

Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression.

Blood - 1 Feb 1995

Berliner N, Hsing A, Graubert T, Sigurdsson F, Zain M, Bruno E, Hoffman R

Abstract excerpt

We have used a combination of hematopoietic growth factors to induce in vitro granulocytic maturation. A fraction of marrow cells enriched for hematopoietic progenitor cells (CD34+, HLA-DR+) was isolated from normal human bone marrow by monoclonal antibody staining and fluorescence-activated cell sorting. Cells were cultured in a suspension system for 3 days in the presence of stem cell factor and interleukin-3...

Topics

Antigens, CD
Antigens, CD34
Bone Marrow
Bone Marrow Cells
Cell Differentiation
Cells, Cultured
Gene Expression
Granulocyte Colony-Stimulating Factor
Granulocytes
HLA-DR Antigens
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kinetics

Lactoferrin

Mucins

Neutrophils

Peroxidase

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7530510

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7530510-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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