Article
DNA double-strand break repair in two radiation-sensitive mouse mammary carcinoma cell lines.
Mutation research - 1 Jan 1995
Warters R L, Barrows L R, Chen D J
Abstract excerpt
The capacity of two radiation-sensitive clones (SX9 and SX10) of the mouse mammary carcinoma cell line SR1 to rejoin radiation-induced DNA double-strand breaks (DSBs) was determined by pulsed-field agarose gel electrophoresis. DSBs were produced with equivalent efficiency in all three cell lines. Both the SX9 and SX10 cell lines demonstrated a significantly diminished capacity to rejoin radiation-induced DSBs....
Topics
- Animals
- DNA
- DNA Damage
- DNA Repair
- Mammary Neoplasms, Experimental
- Mice
- Mutation
- Radiation Tolerance
- Tumor Cells, Cultured