Article
Molecular characterization of ionizing radiation-hypersensitive mutant M10 cells.
Mutation research - 19 Dec 2001
Mori M, Itsukaichi H, Nakamura A, Sato K
Abstract excerpt
An ionizing radiation-sensitive mutant derivative of mouse lymphoma L5178Y cell, M10, is defective in rejoining DNA double-strand breaks (DSBs). The complementation test and the results of chromosome transfer suggested that M10 may belong to X-ray cross-complementation (XRCC) group 4. In the present study, sequence analysis of Xrcc4 cDNA in M10 cells disclosed a transversion of A (370) to T, which results in a...
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