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Article

Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.

1 Nov 1994

Abstract excerpt

Desmoplakins (DPs) are the most abundant proteins in the innermost portion of the desmosomal plaque and have been proposed to play a role in the attachment of intermediate filaments (IF) to cell-cell contact sites. Our previous results suggest that the globular end domains of DP perform dual functions: first, to target DP to the desmosome via the NH2 terminus and second, to attach IF to the desmosomal plaque via...

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PMID: 7525582
DOI: 10.1016/s0021-9258(18)43881-1

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Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.PMID 7525582Read ↗

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Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytesSemantic proximity Read ↗

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