Article
Appearance of the myofibroblastic phenotype in Dupuytren's disease is associated with a fibronectin, laminin, collagen type IV and tenascin extracellular matrix.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1994
Berndt A, Kosmehl H, Katenkamp D, Tauchmann V
Abstract excerpt
The proliferative nodules of Dupuytren's disease are electron microscopically characterized by the occurrence of myofibroblasts with a basal lamina-like material. As reported in the literature, immunohistochemical investigations showed a fibronectin matrix but failed to demonstrate laminin. This discrepancy between electron microscopic features and immunohistochemical findings prompted us to examine the...
Topics
- Cell Adhesion Molecules, Neuronal
- Collagen
- Dupuytren Contracture
- Extracellular Matrix
- Extracellular Matrix Proteins
- Fibroblasts
- Fibronectins
- Humans
- Immunoblotting
- Immunohistochemistry