Article
Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro.
Oncogene - 12 Jun 2003
Varallo Vincenzo M, Gan Bing Siang, Seney Shannon, Ross Douglas C, Roth James H, Richards Robert S, McFarlane Robert M, Alman Benjamin, Howard Jeffrey C
Abstract excerpt
Dupuytren's disease (DD) is a superficial fibromatosis of the hand. Although the molecular mechanisms responsible for this disease are unknown, recent studies suggest that beta-catenin may be a key factor involved in fibromatosis. In this study, we analysed the in vivo and in vitro expression levels of beta-catenin in DD, using surgical specimens and primary cell lines. Although no somatic mutations (exon 3) of...
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