Article
TGF beta and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin.
The Histochemical journal - 1 Dec 1995
Berndt A, Kosmehl H, Mandel U, Gabler U, Luo X, Celeda D, Zardi L, Katenkamp D
Abstract excerpt
Nodular palmar fibromatosis is a self-limited proliferation of fibro-/myofibroblasts associated with growth factor synthesis and abundant fibronectin extracellular matrix deposition. bFGF and TGF beta are potent modulators of fibro-/myofibroblast proliferation and differentiation. Moreover, in vi...
Topics
- DNA, Complementary
- Dupuytren Contracture
- Fibroblast Growth Factor 2
- Fibroblasts
- Fibronectins
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Oligonucleotide Probes
- Phenotype
- RNA, Messenger
- Transforming Growth Factor beta