Article
On the linkage between RNA processing and RNA translatability.
The Journal of biological chemistry - 7 Oct 1994
Connor A, Wiersma E, Shulman M J
Abstract excerpt
The immunoglobulin mu heavy chain gene of mouse hybridoma cells is expressed in two forms, microseconds and microns, differing in their use of 3' exons. As for many other mammalian genes, mutations in the mu gene which prematurely terminate translation often have the effect of reducing the amount of these mu RNAs. To test the generality of this relationship, we selected mutant hybridoma cell lines defective in...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Exons
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin mu-Chains
- Mice
- Molecular Sequence Data
- Mutation
- Protein Biosynthesis