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Article

Conformational change of the extracellular parts of the CFTR protein during channel gating.

Cellular and molecular life sciences : CMLS - 1 Aug 2018

Negoda Alexander, Cowley Elizabeth A, El Hiani Yassine, Linsdell Paul

Abstract excerpt

Cystic fibrosis can be treated by potentiators, drugs that interact directly with the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel to increase its open probability. These substances likely target key conformational changes occurring during channel opening and closing, however, the molecular bases of these conformational changes, and their susceptibility to manipulation are poorly...

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Source

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Identifiers

PMID: 29441426
DOI: 10.1007/s00018-018-2777-0
PMCID: PMC11105745

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformational change of the extracellular parts of the CFTR protein during channel gating.PMID 29441426Read ↗

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Modeling the Conformational Changes Underlying Channel Opening in CFTRSemantic proximity Read ↗

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Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Semantic proximity Read ↗

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.Semantic proximity Read ↗

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