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Clonal selection and amplification of phage displayed antibodies by linking antigen recognition and phage replication.

Bio/technology (Nature Publishing Company) - 1 Oct 1994

Dueñas M, Borrebaeck C A

Abstract excerpt

The immune response generates a tremendous array of antibody specificities by VDJ-gene rearrangements. A similar diversity can be obtained by expressing entire V-gene repertoires on the surface of filamentous bacteriophages creating large antibody libraries. Here we describe how the clonal selection mechanisms of the humoral immune response can also be mimicked in the phage display system by linking...

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PMID: 7522473
DOI: 10.1038/nbt1094-999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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