Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal selection and amplification of phage displayed antibodies by linking antigen recognition and phage replication.

Bio/technology (Nature Publishing Company) - 1 Oct 1994

Dueñas M, Borrebaeck C A

Abstract excerpt

The immune response generates a tremendous array of antibody specificities by VDJ-gene rearrangements. A similar diversity can be obtained by expressing entire V-gene repertoires on the surface of filamentous bacteriophages creating large antibody libraries. Here we describe how the clonal selection mechanisms of the humoral immune response can also be mimicked in the phage display system by linking...

Topics

Antibodies
Antibody Specificity
Bacteriophage M13
Base Sequence
Capsid
Capsid Proteins
Epitopes
Gene Deletion
Genetic Engineering
Molecular Sequence Data
Muramidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Recombinant Fusion Proteins

Virus Replication

Source

Identifiers

PMID: 7522473
DOI: 10.1038/nbt1094-999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7522473-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal selection and amplification of phage displayed antibodies by linking antigen recognition and phage replication.PMID 7522473Read ↗

Making Antibodies by Phage Display TechnologySemantic proximity Read ↗

Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage displaySemantic proximity Read ↗

Introduction to Antibody Engineering and Phage DisplaySemantic proximity Read ↗

By-passing immunization. Human antibodies from V-gene libraries displayed on phage.Semantic proximity Read ↗

Phage Display Derived Monoclonal Antibodies: From Bench to BedsideSemantic proximity Read ↗

The role of phage display in therapeutic antibody discoverySemantic proximity Read ↗

Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity MaturationSemantic proximity Read ↗

Antibody display technologies: selecting the cream of the cropSemantic proximity Read ↗

Improvement of affinity and potency of a monoclonal antibody against <i>Shigella flexneri</i> 3a O-antigen via phage display and whole-cell in-solution panningSemantic proximity Read ↗

Developing recombinant antibodies by phage display technology to neutralize viral infectious diseasesSemantic proximity Read ↗

Guiding the Selection of Human Antibodies from Phage Display Repertoires to a Single Epitope of an AntigenSemantic proximity Read ↗

Screening of phage antibody libraries.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.