Article
Involvement of membrane bleomycin-binding sites in bleomycin cytotoxicity.
Biochemical pharmacology - 19 Jul 1994
Pron G, Belehradek J, Orlowski S, Mir L M
Abstract excerpt
The authors have recently shown the existence of bleomycin (BLM)-binding sites at the surface of DC-3F cells. In order to study the involvement of these sites in the sensitivity of the cells to bleomycin several BLM-resistant cell lines from DC-3F cells were analysed. These mutants were obtained by electrotransfection of the Sh ble gene (D/BlmI cells) or the Sh ble-beta Gal fusion gene (D/BlmII cells) and/or by...
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