Article
Epstein-Barr virus positivity in Hodgkin's disease does not correlate with an HLA A2-negative phenotype.
Cancer - 15 Jun 1994
Poppema S, Visser L
Abstract excerpt
BACKGROUND: Epstein-Barr virus- (EBV) related DNA and RNA can be found in tissues involved with Hodgkin's disease, specifically in the Reed-Sternberg cells. These cells also express the membrane antigens LMP1 and LMP 2A and 2B. Studies in normal individuals indicate that cellular immunity against LMP2 was frequently mediated through human leukocyte antigen (HLA) A2, whereas responses to LMP1 appeared to be...
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