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EBV in Hodgkin Lymphoma

1 Jan 2009

Abstract excerpt

Up to 40% of Hodgkin lymphoma (HL) cases are associated with the Epstein-Barr virus (EBV). Clonal viral genomes can be found in the HL tumor cells, the Hodgkin Reed-Sternberg cells (HRS). The latent infection results in expression of the viral oncogenes LMP1 and LMP2A which contribute to generate the particular phenotype of the HRS cells. EBV does not only undergo epigenetic changes of its genome during latency,...

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Identifiers

PMID: 21416003
DOI: 10.4084/mjhid.2009.013

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