Article
Comparison of the sites of reaction of three polycyclic aromatic hydrocarbons in the supF gene.
Mutation research - 1 Apr 1994
Ross H L, Lee H, Harvey R G, Dipple A
Abstract excerpt
The distribution of hydrocarbon-DNA adducts through the supF gene in plasmid pS189 was examined using the polymerase arrest assay. For three hydrocarbon dihydrodiol epoxides, derived from 5-methylchrysene, 7-methylbenz[a]anthracene, and benzo[a]pyrene, that exhibit a preference for reaction with guanine residues in DNA, polymerase arrest spectra were similar but not identical. For each agent, guanines in...
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