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Article

Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations.

The American journal of pathology - 1 Sept 1999

Chu P G, Chang K L, Chen W G, Chen Y Y, Shibata D, Hayashi K, Bacchi C, Bacchi M, Weiss L M

Abstract excerpt

Different ethnic groups with a high human leukocyte antigen (HLA)-A11 prevalence have been shown to experience a high rate of Epstein-Barr virus (EBV) infection, EBV-associated malignancies, and Epstein-Barr nuclear antigen (EBNA)-4 mutations. The epitopes 399-408 and 416-424 of EBNA-4 are major antigenic epitopes that elicit an HLA-A11 cytotoxic T lymphocyte (CTL) response to EBV infection. Mutations selectively...

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Identifiers

PMID: 10487851
DOI: 10.1016/S0002-9440(10)65193-0
PMCID: PMC1866909

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Source receipt: pubmed, retrieved 7 Sept 2026.

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