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Article

Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1994

Kast W M, Brandt R M, Sidney J, Drijfhout J W, Kubo R T, Grey H M, Melief C J, Sette A

Abstract excerpt

We have measured the binding affinity for five HLA-A alleles: HLA-A1 (A*0101), A2.1 (A*0201), A3 (A*0301), A11 (A*1101), and A24 (A*2401); of a set of all possible nonamer peptides (n = 240) of human papillomavirus type 16 E6 and E7 proteins. High affinity binding peptides were identified for each of the alleles, thus allowing us to select several candidates for CTL-based vaccines. Moreover, this unbiased set of...

Topics

Alleles
Amino Acid Sequence
Epitopes
Genes, MHC Class I
HLA-A Antigens
Humans
Molecular Sequence Data
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptides

Protein Binding

Repressor Proteins

T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 7511661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7511661-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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