Article
Assembly and extracellular release of chimeric HIV-1 Pr55gag retrovirus-like particles.
Virology - 1 Apr 1994
Wagner R, Deml L, Fliessbach H, Wanner G, Wolf H
Abstract excerpt
The HIV-1 Pr55gag precursors were previously shown to assemble and bud from a variety of different cell types as noninfectious virus-like particles (VLPs) resembling immature HIV virions. The use of these VLPs as an immunogenic and autologous carrier component may allow the presentation of defined epitopes deduced from reading frames other than gag to the immune system, thereby avoiding the induction of adverse...
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