Target determination of neurotransmitter phenotype in sympathetic neurons.

Abstract excerpt

While the majority of sympathetic neurons are noradrenergic, a minority population are cholinergic. At least one population of cholinergic sympathetic neurons arises during development by a target-dependent conversion from an initial noradrenergic phenotype. Evidence for retrograde specification has been obtained from transplantation studies in which sympathetic neurons that normally express a noradrenergic...

Topics

• Animals
• Neurons
• Neurotransmitter Agents
• Phenotype
• Signal Transduction
• Sweat Glands
• Sympathetic Nervous System
• Synapses