[Recent advances in the diagnosis and therapeutics for human prion diseases].

Article

[Recent advances in the diagnosis and therapeutics for human prion diseases].

Nihon rinsho. Japanese journal of clinical medicine - 1 Aug 2007

Sakasegawa Yuji, Doh-ura Katsumi

Abstract excerpt

Prion diseases, or transmissible spongiform encephalopathies, are fatal, neurodegenerative disorders associated with the accumulation of a misfolded infectious prion protein which is made by a posttranslational conformational change of the host-encoded cellular prion protein. A large number of studies to reveal the pathogenesis of prion diseases have been done using such experimental models as animals, cell...

Topics

14-3-3 Proteins
Animals
Biomarkers
Clinical Trials as Topic
Diffusion Magnetic Resonance Imaging
Drug Design
Drug Evaluation, Preclinical
Mutation
Prion Diseases
Prion Proteins
Prions

Protein Folding

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