Article
[Recent advances in the diagnosis and therapeutics for human prion diseases].
Nihon rinsho. Japanese journal of clinical medicine - 1 Aug 2007
Sakasegawa Yuji, Doh-ura Katsumi
Abstract excerpt
Prion diseases, or transmissible spongiform encephalopathies, are fatal, neurodegenerative disorders associated with the accumulation of a misfolded infectious prion protein which is made by a posttranslational conformational change of the host-encoded cellular prion protein. A large number of studies to reveal the pathogenesis of prion diseases have been done using such experimental models as animals, cell...
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