[Genetics of human subacute spongiform encephalopathies].

Abstract excerpt

Variations in PRNP, the gene that encodes PrP in humans, play a major role in the genetic predisposition to prion diseases. Mutations in PRNP are found in patients with familial forms and are considered as causative. A coding polymorphism in PRNP (129 Met/Val) defines a predisposing factor to sporadic and acquired forms. Other favouring genes have been searched without real success. Both animal models and...

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