Article
Field effect of human colon carcinoma on normal mucosa: relevance of carcinoembryonic antigen expression.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 1996
Jothy S, Slesak B, Harłozińska A, Lapińska J, Adamiak J, Rabczyński J
Abstract excerpt
Human colon cancer usually develops on a mucosa which has already undergone multiple steps of genetic change. These multiple steps create a field effect characterized by the presence of morphologically normal, but biologically altered epithelial cells. This aims of this study were to evaluate whether the expression of carcinoembryonic antigen (CEA) can act as a phenotypic marker of the field effect, and to map...
Topics
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Carcinoembryonic Antigen
- Colonic Neoplasms
- Cross Reactions
- Humans
- Intestinal Mucosa
- Phenotype
- Staining and Labeling
- Tissue Distribution