Article
Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 1996
Manohar C F, Salwen H R, Furtado M R, Cohn S L
Abstract excerpt
An early event in the pathogenesis of neuroblastoma (NB), a tumor derived from embryonal neural crest tissue, appears to be the arrested differentiation of neuroblasts. However, NB cells can be induced to differentiate in vitro with numerous chemicals including retinoic acid (RA) and dibutyryl cy...
Topics
- Cell Differentiation
- Gene Expression Regulation, Neoplastic
- Genes, Homeobox
- Humans
- Neuroblastoma
- Phenotype
- Tretinoin
- Tumor Cells, Cultured
- Up-Regulation