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Article

Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 1996

Manohar C F, Salwen H R, Furtado M R, Cohn S L

Abstract excerpt

An early event in the pathogenesis of neuroblastoma (NB), a tumor derived from embryonal neural crest tissue, appears to be the arrested differentiation of neuroblasts. However, NB cells can be induced to differentiate in vitro with numerous chemicals including retinoic acid (RA) and dibutyryl cyclic AMP (db-cAMP). One family of transcription factors, encoded by the homeobox (HOX) genes, plays a crucial role in...

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Source

Identifiers

PMID: 7501971
DOI: 10.1159/000217965

Genes

HOXC6
HOXD8
HOXD1
HOXC8
HOXD4
HOXD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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