Article
Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype.
Cancer research - 15 Aug 1995
Yan N, Ricca C, Fletcher J, Glover T, Seizinger B R, Manne V
Abstract excerpt
Neurofibromatosis type I (NF1) is a hereditary tumor and developmental disorder whose defective gene was cloned previously. The protein product of the NF1 gene, neurofibromin, contains a domain that shows significant sequence homology to the known catalytic domains of mammalian Ras GTPase-activat...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Cell Adhesion
- Cell Compartmentation
- Cell Division
- Farnesyltranstransferase
- Humans
- In Vitro Techniques
- Molecular Sequence Data
- Neurofibromatosis 1
- Oligopeptides
- Phenotype
- Phosphinic Acids
- Protein Prenylation
- Proto-Oncogene Proteins p21(ras)
- Substrate Specificity
- Transferases
- Tumor Cells, Cultured