Article
Molecular characterization of hasC from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose pyrophosphorylase activity.
The Journal of biological chemistry - 1 Dec 1995
Crater D L, Dougherty B A, van de Rijn I
Abstract excerpt
Hyaluronic acid is a high molecular weight glycosaminoglycan composed of repeating subunits of glucuronic acid and N-acetylglucosamine. It is synthesized by the group A streptococcal membrane-associated enzyme hyaluronate synthase. In previous reports, the locus required for expression of hyaluro...
Topics
- Amino Acid Sequence
- Bacteriophage T7
- Base Sequence
- Catalysis
- Cloning, Molecular
- DNA, Recombinant
- Escherichia coli
- Genetic Complementation Test
- Glucosephosphates
- Hyaluronic Acid
- Molecular Sequence Data
- Mutation
- Operon
- Sequence Homology, Amino Acid
- Streptococcus pyogenes
- UTP-Glucose-1-Phosphate Uridylyltransferase
- Uridine Diphosphate Glucose
- Uridine Triphosphate