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Human Papillomavirus DNA Is Rarely Detected in Colorectal Carcinomas and Not Associated with Microsatellite Instability: The Seattle Colon Cancer Family Registry

19 Dec 2012

Abstract excerpt

BACKGROUND: Persistent infection with oncogenic human papillomavirus (HPV) types-16 and -18 is an established cause of cervical and other cancers. Some studies report detection of oncogenic HPV DNA in colorectal carcinomas, with prevalence estimates as high as 84%. However, other studies report detecting no HPV DNA in colorectal tumors. METHODS: To evaluate the prevalence of HPV in colorectal cancer subsets, we...

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PMID: 23250932
DOI: 10.1158/1055-9965.epi-12-1170

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