Analysis of CpG dinucleotide frequency in relationship to translational reading frame suggests a class of genes in which mutation of this dinucleotide is asymmetric with respect to DNA strand.

doi:10.1016/0014-5793(95)01268-3

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Article

Analysis of CpG dinucleotide frequency in relationship to translational reading frame suggests a class of genes in which mutation of this dinucleotide is asymmetric with respect to DNA strand.

FEBS letters - 4 Dec 1995

Leader D P, Peter B, Ehmer B

Abstract excerpt

Results are described from application of a computer program that compares the expected and actual incidence of CpG dinucleotides in relation to the codon reading frame of genes, assuming a conserved amino acid sequence and normalizing for the third-position incidences of C and G in the remainder...

Topics

Actins
Animals
Base Composition
Base Sequence
Codon
DNA, Complementary
Genes
Humans
Mutation
Open Reading Frames
Protein Biosynthesis

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