Article
Anti-B4-blocked ricin synergizes with doxorubicin and etoposide on multidrug-resistant and drug-sensitive tumors.
Blood - 1 Dec 1995
O'Connor R, Liu C, Ferris C A, Guild B C, Teicher B A, Corvi C, Liu Y, Arceci R J, Goldmacher V S, Lambert J M, Blättler W A
Abstract excerpt
Anti-B4-blocked ricin (anti-B4-bR) is an immunotoxin directed against CD19-positive cells that is currently being tested in several B-cell leukemia/lymphoma clinical trials. To explore the possibility of using anti-B4-bR in combination with chemotherapy protocols, we investigated the in vitro and in vivo cytotoxic effects of combining it with doxorubicin or etoposide using the lymphoma cell line Namalwa and a...
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