Article
Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population.
Alcoholism, clinical and experimental research - 1 Sept 1997
Lee K H, Kwak B Y, Kim J H, Yoo S K, Yum S K, Jeong H S
Abstract excerpt
Mitochondrial aldehyde dehydrogenase (ALDH2) is mainly responsible for the oxidation of acetaldehyde generated during alcohol oxidation in vivo. Cytochrome P-4502E1 (CYP2E1), a liver microsomal enzyme, also metabolizes acetaldehyde and ethanol. Genetic polymorphism of ALDH2 and CYP2E1 was investi...
Topics
- Adult
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Base Sequence
- Cytochrome P-450 CYP2E1
- Ethanol
- Gene Frequency
- Genetics, Population
- Genotype
- Humans
- Introns
- Korea
- Mitochondria, Liver
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length