Article
The frequency of the mitochondrial aldehyde dehydrogenase I2 (atypical) allele in Caucasian, Oriental and African black populations determined by the restriction profile of PCR-amplified DNA.
Molecular and cellular probes - 1 Jun 1995
Dandré F, Cassaigne A, Iron A
Abstract excerpt
The aldehyde dehydrogenase I (ALDH I) gene codes for a mitochondrial enzyme which plays a major role in hepatic alcohol detoxication. It has been related to alcohol flushing in Orientals bearing the atypical ALDH I2 gene. The variant protein results from a lysine for glutamate substitution at pos...
Topics
- Aldehyde Dehydrogenase
- Alleles
- Asian People
- Base Sequence
- Black People
- Cambodia
- Congo
- DNA
- France
- Gene Frequency
- Genetics, Population
- Humans
- Mitochondria
- Molecular Sequence Data
- Polymerase Chain Reaction
- Racial Groups
- Vietnam
- White People