Article
Induction of Rod-Shaped Structures by Herpes Simplex Virus Glycoprotein I.
Journal of virology - 17 Aug 2020
Zhang Wuchao, Gao Peng, Gui Xixi, Zhou Lei, Ge Xinna, Guo Xin, Wills John W, Han Jun, Yang Hanchun
Abstract excerpt
The envelope glycoprotein I (gI) of herpes simplex virus 1 (HSV-1) is a critical mediator of virus-induced cell-to-cell spread and cell-cell fusion. Here, we report a previously unrecognized property of this molecule. In transfected cells, the HSV-1 gI was discovered to induce rod-shaped structures that were uniform in width but variable in length. Moreover, the gI within these structures was conformationally...
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